Married first Jane Thomas 23 Jun 1794 in Cecil Co, MD. Listed in Cecil Co, MD in 1800. Moved to Canfield, Trumbull Co, OH about 1802. Gave power of attorney to friends & left family in OH about 1820. Moved to Harrison Co, VA and married Nancy Shaw 15 Oct 1821. Listed in Harrison County census 1830, 1840, 1850.
Children: Levi (c.1824), Isaac (c. 1826), Elizabeth (c. 1827), Martin (c. 1833), Sarah (c. 1835).
Isaac Wilcox Will (written 28 Nov 1850, and produced in Harrison County Court 21 Feb 1853): “To wife Nancy 1/3 of the personal estate I may own at my death and 1/3 of my real estate for her natural life”. “2/3 of my personal estate remaining to my son Martin and my daughter Sarah equally”. “Having a daughter Betsey --- imbecile”. Also mentions son Levi and Isaac and daughter Hannah.